What You Need to know About Odefsey (Emtricitabine, Tenofovir AF, Rilpivirine)

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Cutting edge three-in-one medication offers fewer results 

Odefsey is a solitary pill, a fixed-portion blend drug utilized in the treatment of HIV. Accessible in tablet structure, it tends to be utilized in grown-ups and a few kids. It is included, three distinctive antiretroviral specialists:

  • Emtricitabine, generally called FTC, a nucleoside turnaround transcriptase inhibitor (NRTI) 
  • Rilpivirine, a non-nucleoside turn around transcriptase inhibitor (NNRTI) 
  • Tenofovir alafenamide (TAF), another NRTI 

Odefsey is utilized all alone and doesn’t need any extra medications to accomplish and support viral concealment.

Odefsey works by restraining various phases of HIV’s replication cycle. Both FTC and TAF block a protein considered opposite transcriptase that HIV uses to change its viral RNA into DNA over to “commandeer” the cell’s hereditary hardware. Rilpivirine works also but instead of obstructing the development of twofold abandoned DNA, it ties to the actual protein to hinder its action. oncohiv.com

Odefsey is the second blend antiretroviral to utilize TAF, an “improved” type of tenofovir disoproxil fumarate (TDF) found in the medications Truvada (FTC + TDF) and Atripla (efavirenz + FTC + TDF). In that capacity, it tends to be viewed as an enhancement for TDF-based Complera (FTC + rilpivirine + TDF).


Odefsey was endorsed by the U.S. Food and Drug Administration (FDA) in March 2016 for use in grown-ups and kids weighing at any rate 35 kilograms (77 pounds). It is shown for use in recently treated individuals who have a viral heap of 100,000 or less. 

Odefsey can likewise be utilized to supplant a current treatment (like Complera) if the individual has had an imperceptible viral burden or if nothing else a half year, has no set of experiences of treatment disappointment, and has no protection from any of the antiretrovirals utilized in Odefsey.2

There are no off-name utilizations for Odefsey and no nonexclusive types of the medication.

Prior to Taking 

When determined to have HIV, your primary care physician will arrange a hereditary obstruction test to decide whether you have any medication safe variations in your “viral pool.” Based on the consequences of the test, otherwise called genotyping, your PCP can figure out which antiretrovirals you are delicate to and which you are most certainly not.

On the off chance that you are being changed to Odefsey, your PCP may likewise arrange a phenotypic test wherein your infection is exclusively presented to antiretroviral medications to figure out which ones you are generally touchy to.

Precautionary measures and Contraindications 

Odefsey can cause the intensification of liver-related manifestations in individuals who are contaminated with hepatitis B.4 Because of this, a hepatitis B test will be performed to check on the off chance that you have the sickness, alongside liver capacity tests to assess the situation with your liver. 

Odefsey is contraindicated for use in individuals on meds that can decrease the grouping of rilpivirine in the circulatory system (see “Admonitions and Contraindications” underneath). It is likewise never utilized in individuals who have had a serious touchy response to FTC, rilpivirine, or tenofovir in one or the other structure. 

Rilpivirine can likewise draw out the supposed QT span on an electrocardiogram and possibly lead to a heart cadence problem called torsades de pointes. Your primary care physician should decide whether you ingest any medications that cause QT prolongation and, assuming this is the case, choose whether Odefsey is a sensible choice for you.

Since the different antiretroviral specialists in Odefsey are discharged using the kidneys or liver, Odefsey ought to be utilized with alertness in individuals with previous kidney or liver brokenness as it can prompt harmfulness. Whenever utilized in these conditions, the standard observation of kidney work and additionally liver capacity is fundamental. 

Other Fixed-Dose Combination Antiretrovirals 

Notwithstanding Odefsey, there are 12 other blend tranquilizes that can be taken all alone with one pill every day: 

  • Atripla (efavirenz + FTC + TDF) 
  • Biktarvy (bictegravir + FTC + TAF) 
  • Complera (FTC + rilpivirine + TDF) 
  • Delstrigo (doravirine + lamivudine + TDF) 
  • Dovato (dolutegravir + lamivudine) 
  • Genvoya (cobicistat + elvitegravir + FTC + TAF) 
  • Juluca (dolutegravir + rilpivirine) 
  • Stribild (cobicistat + elvitegravir + FTC + TDF) 
  • Symfi (efavirenz + lamivudine + TDF) 
  • Symfi Lo (efavirenz + lamivudine + TDF) 
  • Symtuza (cobicistat + darunavir + FTC + TAF) 
  • Triumeq (abacavir + dolutegravir + lamivudine)


Odefsey is accessible as a dim, elongated, film-covered tablet, containing 200 milligrams (mg) of FTC, 25 mg of rilpivirine, and 25 mg of TAF. 

Odefsey is taken by mouth once every day with food. 

Since Odefsey is a fixed-portion drug, the portion can’t be altered.

Instructions to Take and Store

Odefsey should be taken with strong food with the end goal for rilpivirine to be appropriately ingested. Protein drinks or dietary beverages won’t do. If not taken with food as recommended, the assimilation of rilpivirine might be decreased by as much as 40%.

Try not to part, pulverize, or bite the tablet, which can likewise influence retention.

Odefsey can be put away securely at room temperature, in a perfect world in its unique light-safe compartment in a cool, dry bureau or cabinet. Continuously check the termination date, disposing of any medications that have lapsed.oncohiv.com


Odefsey may cause results in certain individuals. Most are by and large transient and will resolve throughout days or weeks as your body adjusts to treatment. Numerous individuals experience no results by any stretch of the imagination. 


The most widely recognized results experienced in as numerous as 2% of clients include: 

  • Cerebral pain 
  • Sickness 
  • Fart 
  • Loose bowels 
  • A sleeping disorder 
  • Uncommon dreams 
  • Extreme

In uncommon cases, Odefsey can cause serious results. These regularly include individuals with previous conditions (or who take contraindicated drugs) who have not been fittingly screened. 

The absolute most genuine intricacies related with Odefsey include:

  • Intense intensifications of hepatitis B: Symptoms incorporate weakness, sickness, jaundice (yellowing of the eyes), stomach torment, loss of craving, and dull pee. 
  • Liver harmfulness: Symptoms are like intense hepatitis B however may likewise include rash and fever. 
  • New or deteriorating kidney hindrance: Symptoms may incorporate diminished pee yield, weariness, windedness, sickness, and tissue growing because of liquid maintenance. 
  • Lactic acidosis: The strange development of lactic corrosion in the circulation system can get serious and surprisingly perilous whenever left untreated. 
  • Serious skin responses: Rare instances of medication response with eosinophilia and foundational manifestations (DRESS) have been accounted for in clients, showing extreme rash, rankles, fever, facial expansion, and hepatitis. 
  • Serious melancholy: Major burdensome scenes, including self-destructive musings, have been accounted for in certain clients of rilpivirine. This is for the most part found in individuals under 
  • Torsade de Pointes (TDP): Generally found in individuals who take QT prolongation drugs, TDP manifestations incorporate heart palpitations, wooziness, sickness, cold sweats, chest torment, windedness, and fast heartbeat.

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